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Construction of developmentally inspired periosteum-like tissue for bone regeneration

Medicine and Health

Construction of developmentally inspired periosteum-like tissue for bone regeneration

K. Dai, S. Deng, et al.

This groundbreaking research by Kai Dai and collaborators focuses on innovative periosteum-like tissue engineering using BMP-2-loaded scaffolds. The creation of tissue that mimics natural bone development promises significant advancements in regenerative medicine, especially for older populations. Discover how the addition of chondroitin sulfate enhances bone regenerative capabilities!

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Playback language: English
Abstract
The periosteum, a highly vascularized thin tissue, possesses excellent osteogenic and bone regenerative abilities. This study utilized a bone morphogenetic protein-2 (BMP-2)-loaded scaffold to create periosteum-like tissue (PT) *in vivo*, mimicking mesenchymal condensation during long bone development. BMP-2-induced endochondral ossification proved crucial for PT construction. The generated PTs exhibited a periosteum-like architecture with abundant periosteum-like tissue-derived cells (PTDCs), blood vessels, and osteochondral progenitor cells. Adding chondroitin sulfate (CS) further enhanced PTDC abundance and function, improving regenerative capacity, even in older mice. This biomimetic strategy holds promise for clinical translation.
Publisher
Bone Research
Published On
Jan 03, 2022
Authors
Kai Dai, Shunshu Deng, Yuanman Yu, Fuwei Zhu, Jing Wang, Changsheng Liu
Tags
periosteum
bone regeneration
BMP-2
scaffold
osteogenic
chondroitin sulfate
regenerative medicine

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