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Abstract
This study demonstrates the in vitro construction of engineered steak-like tissue assembled from three types of bovine cell fibers: muscle, fat, and vessel. A novel tendon-gel integrated bioprinting (TIP) technique was developed to construct tendon-like gels, mimicking the aligned structure of real meat. 72 fibers (42 muscle, 28 adipose, 2 blood capillaries) were constructed using TIP and manually assembled into a 5 mm diameter, 10 mm long steak-like structure.
Publisher
Nature Communications
Published On
Aug 24, 2021
Authors
Dong-Hee Kang, Fiona Louis, Hao Liu, Hiroshi Shimoda, Yasutaka Nishiyama, Hajime Nozawa, Makoto Kakitani, Daisuke Takagi, Daijiro Kasa, Eiji Nagamori, Shinji Irie, Shiro Kitano, Michiya Matsusaki
Tags
tissue engineering
bioprinting
bovine cell fibers
muscle tissue
fat tissue
tendon-gel
steak-like structure
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