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Sequential laxative-probiotic usage for treatment of irritable bowel syndrome: a novel method inspired by mathematical modelling of the microbiome

Medicine and Health

Sequential laxative-probiotic usage for treatment of irritable bowel syndrome: a novel method inspired by mathematical modelling of the microbiome

M. Li, R. Xu, et al.

This groundbreaking research by Ming Li, Ri Xu, and Yan-qing Li explores a novel sequential laxative-probiotic treatment for Irritable Bowel Syndrome (IBS), utilizing advanced mathematical modeling of the gut microbiome. The findings reveal that specific treatment regimens can significantly alleviate IBS symptoms and enhance gut health, showcasing an innovative approach to microbiome-targeted therapies.

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Playback language: English
Abstract
This study investigates the efficacy of a novel sequential laxative-probiotic treatment for Irritable Bowel Syndrome (IBS), guided by mathematical modeling of the gut microbiome. A new non-extinction and defecation-normalized (NEDN) model was developed to simulate the gut microbiome's dynamics. In silico simulations suggested that laxatives create favorable conditions for probiotic intervention. A clinical trial comparing three *Clostridium butyricum* (CB) regimens (laxative followed by CB, laxative with a 2-week interval before CB, and CB alone) showed that the sequential laxative-CB regimen optimally relieved IBS symptoms and improved the gut microbiome composition towards a healthier state. These results highlight the potential of integrating mathematical modeling and clinical trials to optimize microbiome-targeted therapies for IBS.
Publisher
Scientific Reports
Published On
Nov 09, 2020
Authors
Ming Li, Ri Xu, Yan-qing Li
Tags
Irritable Bowel Syndrome
laxatives
probiotics
gut microbiome
clinical trial
mathematical modeling
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