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Virulence-determinants and antibiotic-resistance genes of MDR- *E. coli* isolated from secondary infections following FMD-outbreak in cattle

Veterinary Science

Virulence-determinants and antibiotic-resistance genes of MDR- *E. coli* isolated from secondary infections following FMD-outbreak in cattle

A. M. Algammal, H. F. Hetta, et al.

This groundbreaking study explores the prevalence and antibiotic resistance of *E. coli* in cattle post-foot-and-mouth disease outbreak in Egypt. The authors reveal alarming multidrug resistance patterns and significant virulence genes, presenting a critical public health concern. With 100% prevalence of the *phoA* gene and promising treatments identified, this research by Abdelazeem M. Algammal and colleagues sheds light on an urgent issue facing livestock health.

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Playback language: English
Abstract
This study investigated the prevalence, multidrug resistance, virulence genes, and antibiotic resistance genes of *E. coli* isolated from secondary infections in cattle following a foot-and-mouth disease (FMD) outbreak in Egypt. Of 160 samples, 30% (n=48) yielded *E. coli*, with 83.3% showing Congo-red binding. Virulence genes (*phoA*, *hly*, *tsh*, *eaeA*, *sta*, *lt*) were detected, with *phoA* at 100% prevalence. 50% of *E. coli* isolates were multidrug-resistant (MDR) to penicillins, cephalosporins, and carbapenems, harboring *bla<sub>TEM</sub>*, *bla<sub>CTX</sub>*, and *bla<sub>KPC</sub>* genes. Colistin sulfate and levofloxacin showed promising in vitro activity against MDR-*E. coli*. This is the first report on *E. coli* secondary infections following FMD outbreaks, highlighting a public health threat.
Publisher
Scientific Reports
Published On
Nov 13, 2020
Authors
Abdelazeem M. Algammal, Helal F. Hetta, Gaber E. Batiha, Wael N. Hozzein, Waleed M. El Kazzaz, Hany R. Hashem, Ayat M. Tawfik, Reham M. El-Tarabili
Tags
E. coli
multidrug resistance
virulence genes
antibiotic resistance
cattle
foot-and-mouth disease

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