Clarithromycin resistance in *Helicobacter pylori* is a major cause of treatment failure. This study analyzed clarithromycin resistance in 4744 patients from Central Hungary using immunohistochemistry and fluorescence in situ hybridization. A mathematical model was developed to analyze the population dynamics of resistance. Primary resistance (in macrolide-naive patients) was found in 5.5%, primarily due to transmission of resistant bacteria. Secondary resistance was higher in women and associated with prior macrolide use for non-eradication purposes. The model suggests that reducing non-eradication macrolide use would decrease the growth rate of clarithromycin resistance.
Publisher
Nature Communications
Published On
Apr 15, 2021
Authors
Éva Kocsmár, György Miklós Buzás, Ildikó Szirtes, Ildikó Kocsmár, Zsófia Kramer, Attila Szijártó, Petra Fadgyas-Freyler, Kató Szénás, Massimo Rugge, Matteo Fassan, András Kiss, Zsuzsa Schaff, Gergely Röst, Gábor Lotz
Tags
Clarithromycin resistance
Helicobacter pylori
macrolide use
patient analysis
population dynamics
immunohistochemistry
fluorescence in situ hybridization
Related Publications
Explore these studies to deepen your understanding of the subject.
