logo
ResearchBunny Logo
Primary and secondary clarithromycin resistance in *Helicobacter pylori* and mathematical modeling of the role of macrolides

Medicine and Health

Primary and secondary clarithromycin resistance in *Helicobacter pylori* and mathematical modeling of the role of macrolides

É. Kocsmár, G. M. Buzás, et al.

Clarithromycin resistance is a critical challenge in treating *Helicobacter pylori*. This innovative study analyzed data from over 4700 patients in Central Hungary, revealing insights into resistance dynamics and the effects of macrolide use. The research was conducted by a team including Éva Kocsmár and György Miklós Buzás.

00:00
00:00
Playback language: English
Abstract
Clarithromycin resistance in *Helicobacter pylori* is a major cause of treatment failure. This study analyzed clarithromycin resistance in 4744 patients from Central Hungary using immunohistochemistry and fluorescence in situ hybridization. A mathematical model was developed to analyze the population dynamics of resistance. Primary resistance (in macrolide-naive patients) was found in 5.5%, primarily due to transmission of resistant bacteria. Secondary resistance was higher in women and associated with prior macrolide use for non-eradication purposes. The model suggests that reducing non-eradication macrolide use would decrease the growth rate of clarithromycin resistance.
Publisher
Nature Communications
Published On
Apr 15, 2021
Authors
Éva Kocsmár, György Miklós Buzás, Ildikó Szirtes, Ildikó Kocsmár, Zsófia Kramer, Attila Szijártó, Petra Fadgyas-Freyler, Kató Szénás, Massimo Rugge, Matteo Fassan, András Kiss, Zsuzsa Schaff, Gergely Röst, Gábor Lotz
Tags
Clarithromycin resistance
Helicobacter pylori
macrolide use
patient analysis
population dynamics
immunohistochemistry
fluorescence in situ hybridization

Related Publications

Explore these studies to deepen your understanding of the subject.

The role of the private sector in noncommunicable disease prevention and management in low-and middle-income countries: a series of systematic reviews and thematic syntheses
Medicine and Health

The role of the private sector in noncommunicable disease prevention and management in low-and middle-income countries: a series of systematic reviews and thematic syntheses

K. Marshall, P. Beaden, et al.

The sharing economy in the hospitality sector: The role of social interaction, social presence, and reciprocity in eliciting satisfaction and continuance behavior
Business

The sharing economy in the hospitality sector: The role of social interaction, social presence, and reciprocity in eliciting satisfaction and continuance behavior

L. H. Lho, W. Quan, et al.

The influence of the parental child-rearing gender-role attitude on children's social adjustment in single- and two-parent families: the mediating role of intergenerational identity
Education

The influence of the parental child-rearing gender-role attitude on children's social adjustment in single- and two-parent families: the mediating role of intergenerational identity

I. Chen, Y. Wang, et al.

The moderating role of information technology governance in the relationship between board characteristics and continuity management during the Covid-19 pandemic in an emerging economy
Business

The moderating role of information technology governance in the relationship between board characteristics and continuity management during the Covid-19 pandemic in an emerging economy

F. A. Almaqtari, N. H. S. Farhan, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny