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Genotypic antimicrobial resistance characterization of *E. coli* from dairy calves at high risk of respiratory disease administered enrofloxacin or tulathromycin

Veterinary Science

Genotypic antimicrobial resistance characterization of *E. coli* from dairy calves at high risk of respiratory disease administered enrofloxacin or tulathromycin

R. V. Pereira, C. Foditsch, et al.

This groundbreaking study investigates the lasting effects of enrofloxacin and tulathromycin on antimicrobial resistance genes in calves at high risk for bovine respiratory disease. Conducted by R. V. Pereira and colleagues, the results reveal significant findings regarding resistance selection and mutation dynamics in fecal E. coli.

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Playback language: English
Abstract
This study evaluated the longitudinal effect of enrofloxacin or tulathromycin use in calves at high risk of bovine respiratory disease (BRD) on antimicrobial resistance genes and mutations in quinolone resistance-determining regions (QRDR) in fecal *E. coli*. Calves were randomly assigned to enrofloxacin, tulathromycin, or no treatment groups. Fecal samples were collected at enrollment and at 7, 28, and 56 days post-treatment. *aac(6')Ib-cr*, *bla-CTX-M*, *bla-TEM*, *tetA*, and *tetB* resistance genes were detected. The enrofloxacin group showed significantly higher detection of *gyrA* mutated at position 248 at 7 and 28 days compared to the control group. Findings highlight the potential impact of enrofloxacin use on resistance selection and persistence.
Publisher
Scientific Reports
Published On
Nov 09, 2020
Authors
R. V. Pereira, C. Foditsch, J. D. Siler, S. C. Dulièpre, C. Altier, A. Garzon, L. D. Warnick
Tags
antimicrobial resistance
enrofloxacin
tulathromycin
bovine respiratory disease
E. coli
calves
quinolone resistance

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