Medicine and Health

Intersecting social and environmental determinants of multidrug-resistant urinary tract infections in East Africa beyond antibiotic use

K. Keenan, M. Papathomas, et al.

This study explores the intricate factors contributing to multi-drug resistant urinary tract infections in East Africa, revealing associations between social and environmental disadvantages and the risk of MDR UTIs. Conducted by a collaborative team of researchers, it emphasizes the urgent need for targeted interventions in vulnerable communities.

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Abstract

This cross-sectional study investigated the combined impact of behavioral, environmental, socioeconomic, and demographic factors on multi-drug resistant urinary tract infections (MDR UTIs) in East Africa. Using data from 1610 individuals in Kenya, Tanzania, and Uganda, the study found that higher MDR UTI risk was associated with interrelated social and environmental disadvantages, including older age, lower education, chronic illness, resource-deprived households, animal contact, and exposure to human or animal waste. This highlights the need for interventions addressing intersectional socio-environmental disadvantage.

Publisher

Nature Communications

Published On

Oct 31, 2024

Authors

Katherine Keenan, Michail Papathomas, Stephen E. Mshana, Benon Asiimwe, John Kiiru, Andy G. Lynch, Mike Kesby, Stella Neema, Joseph R. Mwanga, Martha F. Mushi, Wei Jing, Dominique L. Green, Emmanuel Olamijuwon, Qing Zhang, Rachel Sippy, Kathryn J. Fredricks, Stephen H. Gillespie, Wilber Sabiiti, Joel Baziras, Derek J. Sloan, Blandina T. Mmbaga, Gibson Kibiki, David Aanensen, John Stelling, V. Anne Smith, Alison Sandeman, Matthew T. G. Holden

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