Medicine and Health

Ultra-durable cell-free bioactive hydrogel with fast shape memory and on-demand drug release for cartilage regeneration

Y. Yang, X. Zhao, et al.

Discover how Yuxuan Yang and colleagues have pioneered a cell-free hydrogel scaffold for cartilage regeneration through an innovative polyaddition reaction. This groundbreaking research not only showcases impressive mechanical properties and drug release capabilities but also highlights the hydrogel's potential to promote stem cell migration and chondrocyte differentiation, leading to effective cartilage regeneration in vivo.

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Abstract

This work constructs a cell-free hydrogel scaffold for cartilage regeneration using a polyaddition reaction with tannic acid and Kartogenin. The hydrogel demonstrates ultra-durable mechanical properties, stage-dependent drug release, fast shape memory, and the ability to alleviate inflammation and regulate oxidative stress. Sequential release of the drugs promotes bone marrow mesenchymal stem cell migration and chondrocyte differentiation, leading to full-thickness cartilage regeneration in vivo.

Publisher

Nature Communications

Published On

Nov 27, 2023

Authors

Yuxuan Yang, Xiaodan Zhao, Shuang Wang, Yanfeng Zhang, Aiming Yang, Yilong Cheng, Xuesi Chen

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