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CAR T-Cell Therapy for Cancer: Latest Updates and Challenges, with a Focus on B-Lymphoid Malignancies and Selected Solid Tumours

Medicine and Health

CAR T-Cell Therapy for Cancer: Latest Updates and Challenges, with a Focus on B-Lymphoid Malignancies and Selected Solid Tumours

H. K. Tang, C. Tang, et al.

Explore the exciting advances in CAR T-cell therapy, which holds future promise for treating common epithelial cancers despite challenges in solid tumors. This review, carried out by Hiu Kwan Tang, Carolyn Tang, Bo Wang, Hui Xian Tan, Muhammad Adeel Sarwar, Bahaaeldin Baraka, Tahir Shafiq, and Ankit R Rao, highlights the biology, mechanisms, and clinical data surrounding this innovative treatment approach.

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Playback language: English
Abstract
This review discusses the limitations of current immunotherapies, the need for new approaches, the biology and mechanism of CAR T-cell therapy, clinical data for anti-CD19 CAR T-cell therapy, treatment toxicity, and the future promise of this treatment for common epithelial cancers. Despite successes in treating refractory CD19-positive B-lymphoid malignancies, challenges remain in applying CAR T-cell technology to solid cancers due to low-level antigen expression on non-malignant cells and limited trafficking to metastatic lesions. However, promising results have been observed in advanced neuroblastoma using anti-GD2 CAR T-cells.
Publisher
Cells
Published On
Jun 08, 2023
Authors
Hiu Kwan Tang, Carolyn Tang, Bo Wang, Hui Xian Tan, Muhammad Adeel Sarwar, Bahaaeldin Baraka, Tahir Shafiq, Ankit R Rao
Tags
CAR T-cell therapy
immunotherapy
CD19
toxicities
neuroblastoma
epithelial cancers
solid tumors
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