Medicine and Health

Highly porous and injectable hydrogels derived from cartilage acellularized matrix exhibit reduction and NIR light dual-responsive drug release properties for application in antitumor therapy

M. Gulfam, S. Jo, et al.

Discover groundbreaking research by Muhammad Gulfam and colleagues on innovative injectable hydrogels that respond to stimuli. These hydrogels, created using biocompatible cartilage acellularized matrix and cutting-edge click chemistry, enable precise drug delivery and targeted treatment. With impressive mechanical properties and minimal drug release under normal conditions, they offer potential breakthroughs in cancer therapy through NIR light activation.

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Abstract

This work details the development of novel stimuli-responsive injectable hydrogels composed of a highly biocompatible cartilage acellularized matrix (CAM) and a water-soluble cross-linker containing a diselenide bridge, utilizing ultrafast norbornene (Nb)-tetrazine (Tz) click chemistry. The hydrogels demonstrate high drug loading, good swelling, and useful mechanical properties. Doxorubicin (DOX) release is minimal under physiological conditions but sustained under reducing conditions. Indocyanine green (ICG) incorporation enables near-infrared (NIR) light-triggered ROS generation and burst DOX release. In vitro studies show biocompatibility and antitumor effects in HT-29 cells after GSH or NIR exposure.

Publisher

NPG Asia Materials

Published On

Authors

Muhammad Gulfam, Sung-Han Jo, Sung-Woo Jo, Trung Thang Vu, Sang-Hyug Park, Kwon Taek Lim

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