Chronic pancreatitis (CP) is a fibro-inflammatory syndrome. This study hypothesized that a soy-tomato enriched diet could reduce inflammation and CP severity. C57BL/6 mice with caerulein-induced CP were fed either a control or soy-tomato diet for two weeks. The soy-tomato diet significantly reduced inflammation and CP severity (p=0.032), improving serum lipase and amylase levels (p<0.05), and reducing inflammatory factors (TNF-α, IL-1β, IL-5) and MDSCs (p<0.05). Infrared sensing showed improved activity and health in soy-tomato fed mice. These results suggest a soy-tomato enriched diet may be a novel treatment for CP.
Publisher
Scientific Reports
Published On
Dec 11, 2020
Authors
Debasmita Mukherjee, Mallory J. DiVincenzo, Molly Torok, Fouad Choueiry, Rahul J. Kumar, Anna Deems, Jenna L. Miller, Alice Hinton, Connor Geraghty, Jose Angel Maranon, Samuel K. Kulp, Christopher Coss, William E. Carson III, Darwin L. Conwell, Phil A. Hart, Jessica L. Cooperstone, Thomas A. Mace
Tags
chronic pancreatitis
soy-tomato diet
inflammation reduction
mouse study
treatment
health improvement
serum levels
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