Medicine and Health

Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity: A nationwide cohort study with validation of the SARS-CoV-2 diagnosis of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG)

A. J. M. Aabakke, T. G. Petersen, et al.

This nationwide cohort study in Denmark explores the critical link between SARS-CoV-2 infection during pregnancy and its impact on maternal health and pregnancy outcomes. The findings reveal heightened risks of hypertensive disorders, early pregnancy loss, preterm delivery, and small-for-gestational-age infants, particularly with hospital admissions amplifying these risks. The research was conducted by a team of experts including Anna J M Aabakke and Tanja G Petersen, among others.

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Abstract

This nationwide cohort study in Denmark investigated the association between SARS-CoV-2 infection during pregnancy and maternal characteristics, pregnancy outcomes, and disease severity (hospital admission). The study validated SARS-CoV-2 diagnoses from national registers against medical records. Results showed increased risks of hypertensive disorders, early pregnancy loss, preterm delivery, and small-for-gestational-age infants among infected women. Hospital admission amplified these risks. Register data showed acceptable validity for identifying SARS-CoV-2 infection during pregnancy.

Publisher

Acta Obstet Gynecol Scand

Published On

Jan 01, 2023

Authors

Anna J M Aabakke, Tanja G Petersen, Karen Wøjdemann, Mette H Ibsen, Fjola Jonsdottir, Elisabeth Rønneberg, Charlotte S Andersen, Anne Hammer, Tine D Clausen, Julie Milbak, Lars Burmester, Rikke Zethner, Birgitte Lindved, Annette Thorsen-Meyer, Mohammed R Khalil, Birgitte Henriksen, Lisbeth Jønsson, Lise L T Andersen, Kamilla K Karlsen, Monica L Pedersen, Gitte Hedermann, Marianne Vestgaard, Dorthe Thisted, Agnethe N Fallesen, Josephine N Johansson, Ditte C Møller, Greta Dubietyte, Charlotte B Andersson, Richard Farlie, Ane-Kersti Skaarup Knudsen, Lea Hansen, Lone Hvidman, Anne N Sørensen, Sidsel L Rathcke, Katrine H Rubin, Lone K Petersen, Jan S Jørgensen, Lone Krebs, Mette Bliddal

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