This study investigated the impact of obesity on kidney function in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). 1002 patients were randomized to a Mediterranean diet or a low-fat diet for 5 years. Patients with Obesity/T2DM had the lowest baseline eGFR and highest uACR. The Mediterranean diet showed a lower eGFR decline and reduced uACR in Obesity/T2DM patients compared to the low-fat diet. Obesity exacerbated kidney dysfunction in T2DM patients. The Mediterranean diet was more beneficial for preserving kidney function in patients with T2DM and obesity.
Publisher
Nutrition and Diabetes
Published On
May 16, 2024
Authors
Alicia Podadera-Herreros, Antonio P. Arenas-de Larriva, Francisco M. Gutierrez-Mariscal, Juan F. Alcala-Diaz, Ana Ojeda-Rodriguez, Fernando Rodriguez-Cantalejo, Magdalena P. Cardelo, Diego Rodriguez-Cano, Jose D. Torres-Peña, Raul M. Luque, Jose M. Ordovas, Pablo Perez-Martinez, Javier Delgado-Lista, Jose Lopez-Miranda, Elena M. Yubero-Serrano
Tags
Obesity
Kidney function
Type 2 diabetes
Coronary heart disease
Mediterranean diet
eGFR
uACR
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