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A comparative study of COVID-19 transcriptional signatures between clinical samples and preclinical cell models in the search for disease master regulators and drug repositioning candidates
Medicine and HealthVirus Research

A comparative study of COVID-19 transcriptional signatures between clinical samples and preclinical cell models in the search for disease master regulators and drug repositioning candidates

H. Chapola, M. A. D. Bastiani, et al.

This groundbreaking research by Henrique Chapola, Marco Antônio De Bastiani, Marcelo Mendes Duarte, Matheus Becker Freitas, Jussara Severo Schuster, Daiani Machado De Vargas, and Fábio Klamt uncovers critical COVID-19 master regulators and explores potential drug repositioning candidates through an innovative comparison of clinical lung autopsy samples and preclinical cell models. Discover how these findings bridge the gap between lab results and real-world applications in treating this pandemic illness.... show more
GeneralSummaryMetrics
Abstract
Publisher
Virus Research
Published On
Jan 26, 2023
Authors
Henrique Chapola, Marco Antônio De Bastiani, Marcelo Mendes Duarte, Matheus Becker Freitas, Jussara Severo Schuster, Daiani Machado De Vargas, Fábio Klamt
DOI
https://doi.org/10.1016/j.virusres.2023.199053
Tags
COVID-19transcriptional signaturesdrug repositioninggene expressionmaster regulatorscell modelsclinical samples
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