Health and Fitness

MyD88 determines the protective effects of fish oil and perilla oil against metabolic disorders and inflammation in adipose tissue from mice fed a high-fat diet

F. Wang, M. Hu, et al.

Discover how fish oil and perilla oil compare in combating metabolic disorders and inflammation in mice. This innovative study by Feng Wang, Mingyuan Hu, Hangju Zhu, Chao Yang, Hui Xia, Xian Yang, Ligang Yang, and Guiju Sun reveals that plant-based ω-3 PUFAs are a promising alternative to marine sources. Dive into the findings that could change dietary recommendations!

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Abstract

This study investigated the comparative effects of fish oil (FO) and perilla oil (PO) on metabolic disorders and inflammation in mice fed a high-fat diet. Both FO and PO showed similar benefits in reducing body weight, glucose, insulin, triglycerides, and total cholesterol, and in decreasing inflammation markers. These effects were found to be dependent on the MyD88 pathway of TLR4 signaling. The findings suggest that plant-based ω-3 PUFAs, such as those in PO, offer a viable alternative to marine ω-3 PUFAs.

Publisher

Nutrition and Diabetes

Published On

Jun 17, 2021

Authors

Feng Wang, Mingyuan Hu, Hangju Zhu, Chao Yang, Hui Xia, Xian Yang, Ligang Yang, Guiju Sun

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