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Abstract
This study uses single-cell analysis of two severe COVID-19 patients before and after tocilizumab treatment to identify a monocyte subpopulation contributing to cytokine storms. Tocilizumab treatment effectively reduced inflammation while maintaining humoral and cellular antiviral immune responses. The study provides insights into tocilizumab's therapeutic effects and potential targets for treating cytokine storms in COVID-19.
Publisher
NATURE COMMUNICATIONS
Published On
Aug 06, 2020
Authors
Chuang Guo, Huan Ma, Xiaofang Wang, Pengfei Cai, Qiaoni Yu, Lin Zhu, Liying Jin, Chen Jiang, Jingwen Fang, Qian Liu, Dandan Zong, Wen Zhang, Yichen Lu, Kun Li, Xuyuan Gao, Bingqing Fu, Lianxin Liu, Xiaoling Ma, Jianping Weng, Haiming Wei, Tengchuan Jin, Jun Lin, Kun Qu
Tags
COVID-19
tocilizumab
cytokine storms
monocyte subpopulation
single-cell analysis
immune responses
inflammation

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