Medicine and Health

Critical roles of cytokine storm and bacterial infection in patients with COVID-19: therapeutic potential of mesenchymal stem cells

B. Arjmand, S. Alavi-moghadam, et al.

Explore the promising therapeutic potential of mesenchymal stem cells (MSCs) in the management of COVID-19 complications. This insightful review by Babak Arjmand, Sepideh Alavi-Moghadam, and others unravels the immunopathology and pathophysiological mechanisms of the disease, highlighting the role of MSCs in combating cytokine storms and bacterial co-infections.

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Playback language: English

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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global health crisis. This virus can lead to a range of symptoms, from mild upper respiratory infections to life-threatening complications like cytokine storm and multi-organ dysfunction. Secondary bacterial co-infection further complicates prognosis. This review explores the immunopathology and pathophysiological mechanisms of COVID-19, including cytokine storm and bacterial co-infection, and discusses the therapeutic potential of mesenchymal stem cells (MSCs) in managing these complications. MSCs offer promise due to their immunomodulatory and regenerative properties, potentially mitigating the effects of an overactive immune system and promoting tissue repair.

Publisher

Inflammopharmacology

Published On

Jan 04, 2023

Authors

Babak Arjmand, Sepideh Alavi-Moghadam, Masoumeh Sarvari, Mostafa Rezaei-Tavirani, Ahmad Rezazadeh-Mafi, Rasta Arjmand, Mohsen Nikandish, Ensieh Nasli-Esfahani, Bagher Larijani

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