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Single-cell analysis of chromatin and expression reveals age- and sex-associated alterations in the human heart

Medicine and Health

Single-cell analysis of chromatin and expression reveals age- and sex-associated alterations in the human heart

D. F. Read, G. T. Booth, et al.

Explore the groundbreaking research by David F. Read and colleagues, which unveils age- and sex-related changes in the human heart at a single-cell level. This study reveals important epigenetic signatures and metabolic alterations, providing a fresh perspective on cardiac aging through extensive cellular analysis.

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Playback language: English
Abstract
This study investigated age- and sex-associated alterations in the human heart at the single-cell level using single-nucleus combinatorial indexing (sci) ATAC- and RNA-sequencing. The researchers identified hundreds of differentially expressed genes by age and sex, revealing epigenetic signatures and variations in metabolic and immune processes across different cell types. They also compared adult and fetal ATAC-Seq profiles to identify developmental stage-specific regulatory factors and built predictive models of cell-type-specific RNA expression using ATAC-Seq profiles to link regulatory sequences to promoters. This research represents the largest single-cell analysis of cardiac aging by age and sex to date.
Publisher
Communications Biology
Published On
Jul 11, 2024
Authors
David F. Read, Gregory T. Booth, Riza M. Daza, Dana L. Jackson, Rula Green Gladden, Sanjay R. Sivatsan, Brent Ewing, Jennifer M. Franks, Cailyn H. Spurrell, Anne Roshella Gomes, Diana O'Day, Aishwarya A. Gogate, Beth K. Martin, Haleigh Larson, Christian Pfleger, Lea Starita, Ying Lin, Jay Shendure, Shin Lin, Cole Trapnell
Tags
cardiac aging
single-cell analysis
epigenetic signatures
RNA-sequencing
ATAC-Seq
age and sex differences
cell-type-specific regulation
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