Medicine and Health

Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm

C. Guo, H. Ma, et al.

This cutting-edge study by Chuang Guo, Huan Ma, and colleagues delves into single-cell analysis of severe COVID-19 patients, revealing a specific monocyte subpopulation linked to cytokine storms. The research showcases how tocilizumab effectively mitigates inflammation while preserving vital immune responses, paving the way for better treatment strategies against COVID-19's severe complications.

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Abstract

This study uses single-cell analysis of two severe COVID-19 patients before and after tocilizumab treatment to identify a monocyte subpopulation contributing to cytokine storms. Tocilizumab treatment effectively reduced inflammation while maintaining humoral and cellular antiviral immune responses. The study provides insights into tocilizumab's therapeutic effects and potential targets for treating cytokine storms in COVID-19.

Publisher

NATURE COMMUNICATIONS

Published On

Aug 06, 2020

Authors

Chuang Guo, Huan Ma, Xiaofang Wang, Pengfei Cai, Qiaoni Yu, Lin Zhu, Liying Jin, Chen Jiang, Jingwen Fang, Qian Liu, Dandan Zong, Wen Zhang, Yichen Lu, Kun Li, Xuyuan Gao, Bingqing Fu, Lianxin Liu, Xiaoling Ma, Jianping Weng, Haiming Wei, Tengchuan Jin, Jun Lin, Kun Qu

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