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Prior SARS-CoV-2 Infection Enhances Initial mRNA Vaccine Response with a Lower Impact on Long-Term Immunity

Biology

Prior SARS-CoV-2 Infection Enhances Initial mRNA Vaccine Response with a Lower Impact on Long-Term Immunity

Silva-moraes, Souquette, et al.

This study reveals intriguing insights into the adaptive immune responses generated after three doses of the Pfizer BNT162b2 mRNA vaccine in both SARS-CoV-2-naive and preimmune individuals. Conducted by Silva-Moraes, Souquette, A Sautto, Ida Paciello, Giada Antonelli, Emanuele Andreano, Rappuoli, Andr M Ea Teixeira-Carvalho, and DrTed M Ross, it highlights how prior infections significantly influence antibody levels while emphasizing the overall immune memory after vaccination.

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Playback language: English
Abstract
This study investigated the adaptive immune responses after three doses of the Pfizer BNT162b2 mRNA vaccine in SARS-CoV-2-naive and preimmune individuals. IgG, B cell, and T cell Spike-specific responses were assessed. Prior infection significantly increased neutralizing antibodies and specific CD4+ T cell subsets, but the long-term benefit was minimal. Both groups showed similar immune memory quality and quantity after the three-dose regimen. The study provides insights into the durability of mRNA vaccine-induced immunity and the effects of preimmunity.
Publisher
ImmunoHorizons
Published On
Sep 15, 2023
Authors
Silva-Moraes, Souquette, A Sautto, Ida Paciello, Giada Antonelli, Emanuele Andreano, Rappuoli, Andr M Ea Teixeira-Carvalho, DrTed M Ross
Tags
adaptive immune response
Pfizer BNT162b2
mRNA vaccine
neutralizing antibodies
SARS-CoV-2
immunity
CD4+ T cells
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