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Long-term effects of SARS-CoV-2 infection on human brain and memory

Biology

Long-term effects of SARS-CoV-2 infection on human brain and memory

Q. Ding and H. Zhao

Discover the intriguing neurological effects of SARS-CoV-2 as examined by Qiulu Ding and Hanjun Zhao. This review delves into how the virus infiltrates the brain, impacts memory, and the role of various biological factors in long COVID. Learn about potential strategies to mitigate these effects.

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Playback language: English
Abstract
This review examines the long-term neurological effects of SARS-CoV-2 infection, focusing on its impact on the brain and memory. It explores the molecular mechanisms by which SARS-CoV-2 invades the brain, including direct infection via olfactory nerves, hematogenous spread, and infection via the optic nerve. The review details the role of ACE2 and other host factors in supporting viral replication and discusses the detrimental effects of SARS-CoV-2-mediated syncytia formation. The impact on memory storage regions of the brain is analyzed, along with the potential mechanisms involving direct viral infection, immune dysfunction, and persistent infection. Risk factors for long COVID, including cytokine storms, autoantibodies, and microclots, are considered, alongside strategies for reducing the incidence of long COVID, such as vaccination, antiviral treatments, and lifestyle modifications.
Publisher
Cell Death Discovery
Published On
May 17, 2023
Authors
Qiulu Ding, Hanjun Zhao
Tags
SARS-CoV-2
neurological effects
memory
long COVID
brain invasion
immune dysfunction
viral replication

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