Medicine and Health

Persistence in risk and effect of COVID-19 vaccination on long-term health consequences after SARS-CoV-2 infection

I. C. H. Lam, R. Zhang, et al.

This comprehensive study involving over a million SARS-CoV-2 patients, conducted by Ivan Chun Hang Lam and colleagues, unveils the long-term health risks of COVID-19 infection and highlights the protective role of vaccinations. Discover how complete vaccination can significantly reduce the risk of major health issues and mortality in the months following infection.

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Playback language: English

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Abstract

This retrospective cohort study (n=1,175,277 SARS-CoV-2 infected patients) investigated the persistent risk of long-term health consequences following SARS-CoV-2 infection and the protective effects of COVID-19 vaccination. Results showed a progressive reduction in all-cause mortality risk over one year post-infection compared to controls. Complete vaccination or booster doses significantly lowered the risk of major cardiovascular diseases and all-cause mortality 30-90 days post-infection. The risk remained significantly higher in unvaccinated and incompletely vaccinated individuals for up to a year. This real-world evidence supports the effectiveness of COVID-19 vaccines in mitigating long-term health risks associated with SARS-CoV-2 infection.

Publisher

Nature Communications

Published On

Feb 26, 2024

Authors

Ivan Chun Hang Lam, Ran Zhang, Kenneth Keng Cheung Man, Carlos King Ho Wong, Celine Sze Lung Chui, Francisco Tsz Tsun Lai, Xue Li, Esther Wai Yin Chan, Chak Sing Lau, Ian Chi Kei Wong, Eric Yuk Fai Wai

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