This Italian multicentric retrospective study aimed to investigate the possible changes in outcomes of patients undergoing surgery for gastrointestinal cancers during the COVID-19 pandemic. The primary endpoint was to determine whether the pandemic scenario increased the rate of patients with colorectal, gastroesophageal, and pancreatic cancers resected at an advanced stage in 2020 compared to 2019. Results showed no significant difference in advanced-stage cancer resection rates between 2020 and 2019. However, the second half of 2020 showed a trend towards higher advanced cancer resection rates. The pandemic significantly impacted perioperative and postoperative outcomes, including increased Charlson Comorbidity Index scores, neoadjuvant treatments, urgent diagnoses, and positive lymph nodes.

Giuseppe Giuliani, Francesco Guerra, Simona Messinese, Francesco Santelli, Lucia Salvischiani, Sofia Esposito, Luca Ferraro Al, Alessandro Esposito, Matteo De Pastena, Daniela Rega, Paolo Delrio, Carlotta La Raja, Antonino Spinelli, Simonetta Massaron, Paola De Nardi, EmanueleFederico Kauffmann, Ugo Boggi, Simona Deidda, Angelo Restivo, Alessandra Marano, Felice Borghi, Micaela Piccoli, Norma Depalma, Stefano D'ugo, Marcello Spampinato, Federico Cozzani, Paolo Del Rio, Rosa Marcellinaro, Massimo Carlini, Raffaele De Rosa, Stefano Scabini, Fabio Maiello, Roberto Polastri, Giulia Turri, Corrado Pedrazzani, Monica Zese, Dario Parini, Andrea Casaril, Gianluigi Moretto, Antonio De Leo, Marco Catarci, Renza Trapani, Sandro Zonta, Patrizia Marsanic, Andrea Muratore, Gregorio Di Franco, Luca Morelli, Alessandro Coppola, Damiano Caputo, Jacopo Andreuccetti, Giusto Pignata, Laura Mastrangelo, Elio Jovine, Michele Mazzola, Giovanni Ferrari, Lorenzo Mariani, Graziano Ceccarelli, Rocco Giuseppe, Stefano Bolzon, Mariateresa Grasso, Silvio Testa, Paola Germani, Niccolò De Manzini, Serena Langella, Alessandro Ferrero, Diego Coletta, Paolo Pietro Bianchi Al, Carmelo Bengala, Andrea Coratti