Prior SARS-CoV-2 Infection Enhances Initial mRNA Vaccine | ResearchBunny

Index

Abstract

This study investigated the adaptive immune responses after three doses of the Pfizer BNT162b2 mRNA vaccine in SARS-CoV-2-naive and preimmune individuals. IgG, B cell, and T cell Spike-specific responses were assessed. Prior infection significantly increased neutralizing antibodies and specific CD4+ T cell subsets, but the long-term benefit was minimal. Both groups showed similar immune memory quality and quantity after the three-dose regimen. The study provides insights into the durability of mRNA vaccine-induced immunity and the effects of preimmunity.

Publisher

ImmunoHorizons

Published On

Sep 15, 2023

Authors

Silva-Moraes, Souquette, A Sautto, Ida Paciello, Giada Antonelli, Emanuele Andreano, Rappuoli, Andr M Ea Teixeira-Carvalho, DrTed M Ross

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