This randomized, placebo-controlled clinical trial investigated the preventive effect of ramelteon on emergence agitation after general anesthesia in children undergoing tonsillectomy. Fifty patients were enrolled, with 48 analyzed. There was no significant difference in emergence agitation incidence (76.6% in both groups) or secondary outcomes between the ramelteon (0.1 mg·kg⁻¹) and placebo groups. The study concludes that this dose of ramelteon does not prevent emergence agitation in this population.
Publisher
Scientific Reports
Published On
Dec 15, 2020
Authors
Maya Komazaki, Takahiro Mihara, Nobuhito Nakamura, Koui Ka, Takahisa Goto
Tags
ramelteon
emergence agitation
general anesthesia
tonsillectomy
children
clinical trial
placebo-controlled
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