Medicine and Health

The effects of omega 3 fatty acids on the serum concentrations of pro inflammatory cytokines and depression status in patients with bipolar disorder: A randomized double-blind controlled clinical trial

H. Eslahi, M. Shakiba, et al.

This groundbreaking clinical trial, conducted by Hadi Eslahi and colleagues, explores the remarkable effects of omega-3 fatty acid supplementation on inflammation and depression in bipolar disorder patients. With promising results showcasing significant reductions in both depression scores and pro-inflammatory cytokines, this research highlights the potential of omega-3 as an effective adjunct therapy.

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Abstract

This randomized clinical trial investigated the effects of omega-3 fatty acid supplementation on pro-inflammatory cytokines and depression in bipolar disorder patients. Sixty patients were randomized to receive either 2g of omega-3 fatty acids or a placebo daily for two months. The omega-3 group showed significant reductions in depression scores and serum concentrations of TNF-α, IL-6, and hs-CRP compared to the placebo group (P < 0.001). A positive correlation existed between cytokine levels and depression scores. Omega-3 supplementation may be a beneficial adjunct therapy for reducing inflammation and depression in bipolar disorder.

Publisher

Journal of Research in Medical Sciences

Published On

Jan 01, 2023

Authors

Hadi Eslahi, Mansour Shakiba, Mohsen Saravani, Abolfazl Payandeh, Mansour Shahraki

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