logo
ResearchBunny Logo
Phage-microbe dynamics after sterile faecal filtrate transplantation in individuals with metabolic syndrome: a double-blind, randomised, placebo-controlled clinical trial assessing efficacy and safety

Medicine and Health

Phage-microbe dynamics after sterile faecal filtrate transplantation in individuals with metabolic syndrome: a double-blind, randomised, placebo-controlled clinical trial assessing efficacy and safety

K. Wortelboer, P. A. D. Jonge, et al.

This groundbreaking pilot study by Koen Wortelboer, Patrick A. de Jonge, Torsten P. M. Scheithauer, Ilias Attaye, E. Marleen Kemper, Max Nieuwdorp, and Hilde Herrema explores the effects of fecal filtrate transplantation on glucose metabolism and gut phageome in individuals with metabolic syndrome, suggesting that gut phage administration can safely alter the gut microbiota.

00:00
00:00
Playback language: English
Abstract
This double-blind, randomized, placebo-controlled pilot study investigated the effects of fecal filtrate transplantation (FFT) on glucose metabolism and gut phageome in individuals with metabolic syndrome. While overall changes in glucose metabolism weren't significantly different between the FFT and placebo groups, FFT was well-tolerated. Phage virion composition significantly altered two days post-FFT, correlating with more virulent phage-microbe interactions. The study suggests safe gut phage administration to transiently alter the gut microbiota.
Publisher
Nature Communications
Published On
Sep 12, 2023
Authors
Koen Wortelboer, Patrick A. de Jonge, Torsten P. M. Scheithauer, Ilias Attaye, E. Marleen Kemper, Max Nieuwdorp, Hilde Herrema
Tags
fecal filtrate transplantation
glucose metabolism
metabolic syndrome
gut phageome
phage-microbe interactions

Related Publications

Explore these studies to deepen your understanding of the subject.

The effects of omega 3 fatty acids on the serum concentrations of pro inflammatory cytokines and depression status in patients with bipolar disorder: A randomized double-blind controlled clinical trial
Medicine and Health

The effects of omega 3 fatty acids on the serum concentrations of pro inflammatory cytokines and depression status in patients with bipolar disorder: A randomized double-blind controlled clinical trial

H. Eslahi, M. Shakiba, et al.

Efficacy of early PET-CT directed switch to carboplatin and paclitaxel based definitive chemoradiotherapy in patients with oesophageal cancer who have a poor early response to induction cisplatin and capecitabine in the UK: a multi-centre randomised controlled phase II trial
Medicine and Health

Efficacy of early PET-CT directed switch to carboplatin and paclitaxel based definitive chemoradiotherapy in patients with oesophageal cancer who have a poor early response to induction cisplatin and capecitabine in the UK: a multi-centre randomised controlled phase II trial

S. Mukherjee, C. N. Hurt, et al.

Efficacy of green jackfruit flour as a medical nutrition therapy replacing rice or wheat in patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study
Medicine and Health

Efficacy of green jackfruit flour as a medical nutrition therapy replacing rice or wheat in patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study

A. G. Rao, K. S. Naik, et al.

A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression
Medicine and Health

A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression

P. R. Shiroma, P. Thuras, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny