This double-blind, randomized, placebo-controlled pilot study investigated the effects of fecal filtrate transplantation (FFT) on glucose metabolism and gut phageome in individuals with metabolic syndrome. While overall changes in glucose metabolism weren't significantly different between the FFT and placebo groups, FFT was well-tolerated. Phage virion composition significantly altered two days post-FFT, correlating with more virulent phage-microbe interactions. The study suggests safe gut phage administration to transiently alter the gut microbiota.
Publisher
Nature Communications
Published On
Sep 12, 2023
Authors
Koen Wortelboer, Patrick A. de Jonge, Torsten P. M. Scheithauer, Ilias Attaye, E. Marleen Kemper, Max Nieuwdorp, Hilde Herrema
Tags
fecal filtrate transplantation
glucose metabolism
metabolic syndrome
gut phageome
phage-microbe interactions
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