Medicine and HealthMucosal Immunology
Perturbation of the gut microbiome by *Prevotella* spp. enhances host susceptibility to mucosal inflammation
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This groundbreaking study reveals how colonization of mice with Prevotella intestinalis worsens intestinal inflammation by modifying the gut microbiome and reducing vital short-chain fatty acids. Notably, IL-18 levels drop significantly, leading to increased inflammation. However, supplementation with IL-18 shows promise in mitigating this response. These insights from Aida Iljazovic and colleagues could reshape our understanding of metabolic shifts in gut health.
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