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Perturbation of the gut microbiome by *Prevotella* spp. enhances host susceptibility to mucosal inflammation

Medicine and Health

Perturbation of the gut microbiome by *Prevotella* spp. enhances host susceptibility to mucosal inflammation

A. Iljazovic, U. Roy, et al.

This groundbreaking study reveals how colonization of mice with Prevotella intestinalis worsens intestinal inflammation by modifying the gut microbiome and reducing vital short-chain fatty acids. Notably, IL-18 levels drop significantly, leading to increased inflammation. However, supplementation with IL-18 shows promise in mitigating this response. These insights from Aida Iljazovic and colleagues could reshape our understanding of metabolic shifts in gut health.

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