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Impact of the gut microbiome on immunological responses to COVID-19 vaccination in healthy controls and people living with HIV

Medicine and Health

Impact of the gut microbiome on immunological responses to COVID-19 vaccination in healthy controls and people living with HIV

S. Ray, A. Narayanan, et al.

Discover how the gut microbiota influences the immune response to the BNT162b2 mRNA SARS-CoV-2 vaccine, especially in immunocompromised individuals such as people living with HIV. This intriguing study, conducted by a team of researchers from Karolinska Institutet, reveals potential avenues for optimizing vaccine efficacy through microbiome modulation.

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Playback language: English
Abstract
mRNA SARS-CoV-2 vaccines, while generally safe and effective, can elicit poor immunogenic responses in immunocompromised individuals, including people living with HIV (PLWH). This study investigated whether baseline gut microbiota predicts immune responses to the BNT162b2 mRNA SARS-CoV-2 vaccine in healthy controls and PLWH. Individuals with high spike IgG titers and high spike-specific CD4⁺ T-cell responses showed low gut α-diversity. *Bifidobacterium* and *Faecalibacterium* were associated with higher spike IgG titers, while *Cloacibacillus* was associated with lower titers. The findings suggest that microbiome modulation could optimize SARS-CoV-2 mRNA vaccine immunogenicity.
Publisher
npj Biofilms and Microbiomes
Published On
Dec 20, 2023
Authors
Shilpa Ray, Aswathy Narayanan, Jan Vesterbacka, Ola Blennow, Puran Chen, Yu Gao, Giorgio Gabarrini, Hans-Gustaf Ljunggren, Marcus Buggert, Lokeshwaran Manoharan, Margaret Sällberg Chen, Soo Aleman, Anders Sönnerborg, Piotr Nowak
DOI
https://doi.org/10.21203/rs.3.rs-2492839/v1
Tags
SARS-CoV-2
mRNA vaccines
gut microbiota
immune response
immunocompromised
HIV
BNT162b2

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