logo
ResearchBunny Logo
Perturbation of the gut microbiome by *Prevotella* spp. enhances host susceptibility to mucosal inflammation

Medicine and Health

Perturbation of the gut microbiome by *Prevotella* spp. enhances host susceptibility to mucosal inflammation

A. Iljazovic, U. Roy, et al.

This groundbreaking study reveals how colonization of mice with Prevotella intestinalis worsens intestinal inflammation by modifying the gut microbiome and reducing vital short-chain fatty acids. Notably, IL-18 levels drop significantly, leading to increased inflammation. However, supplementation with IL-18 shows promise in mitigating this response. These insights from Aida Iljazovic and colleagues could reshape our understanding of metabolic shifts in gut health.

00:00
00:00
Playback language: English
Abstract
This study demonstrates that colonization of mice with *Prevotella intestinalis*, a bacterium associated with colitis, exacerbates intestinal inflammation. *P. intestinalis* alters the gut microbiome, reducing short-chain fatty acids (SCFAs), specifically acetate, and consequently decreasing intestinal IL-18 levels. IL-18 supplementation reduced inflammation in *Prevotella*-colonized mice, suggesting that *Prevotella* colonization causes metabolic changes that reduce IL-18 production, thereby worsening intestinal inflammation and potentially systemic autoimmunity.
Publisher
Mucosal Immunology
Published On
May 20, 2020
Authors
Aida Iljazovic, Urmi Roy, Eric J. C. Gálvez, Till R. Lesker, Bei Zhao, Achim Gronow, Lena Amend, Sabine E. Will, Julia D. Hofmann, Marina C. Pils, Kerstin Schmidt-Hohagen, Meina Neumann-Schaal, Till Strowig
Tags
Prevotella intestinalis
intestinal inflammation
short-chain fatty acids
IL-18
gut microbiome
colitis
autoimmunity

Related Publications

Explore these studies to deepen your understanding of the subject.

Targeted delivery of the probiotic *Saccharomyces boulardii* to the extracellular matrix enhances gut residence time and recovery in murine colitis
Medicine and Health

Targeted delivery of the probiotic *Saccharomyces boulardii* to the extracellular matrix enhances gut residence time and recovery in murine colitis

M. K. Heavey, A. Hazelton, et al.

Impact of the gut microbiome on immunological responses to COVID-19 vaccination in healthy controls and people living with HIV
Medicine and Health

Impact of the gut microbiome on immunological responses to COVID-19 vaccination in healthy controls and people living with HIV

S. Ray, A. Narayanan, et al.

Not with the bot! The relevance of trust to explain the acceptance of chatbots by insurance customers
Business

Not with the bot! The relevance of trust to explain the acceptance of chatbots by insurance customers

J. D. Andrés-sánchez and J. Gené-albesa

Large-scale emergence of regional changes in year-to-year temperature variability by the end of the 21st century
Earth Sciences

Large-scale emergence of regional changes in year-to-year temperature variability by the end of the 21st century

D. Olonscheck, A. P. Schurer, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny