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Abstract
Exposure of mice or humans to cold promotes significant changes in brown adipose tissue (BAT) with respect to histology, lipid content, gene expression, and mitochondrial mass and function. This study finds that Perilipin 5 (PLIN5) increases markedly in BAT during cold exposure in mice. Gain- and loss-of-function mouse models demonstrate that PLIN5 augments fatty acid uptake, mitochondrial biogenesis, cristae packing, and oxidative function in BAT. Promoting PLIN5 function in BAT is associated with healthy remodeling of subcutaneous white adipose tissue and improvements in systemic glucose tolerance and diet-induced hepatic steatosis. These findings suggest PLIN5 as a therapeutic target for metabolic diseases.
Publisher
NATURE COMMUNICATIONS
Published On
Jun 03, 2021
Authors
Violeta I. Gallardo-Montejano, Chaofeng Yang, Lisa Hahner, John L. McAfee, Joshua A. Johnson, William L. Holland, Rodrigo Fernandez-Valdivia, Perry E. Bickel
Tags
Perilipin 5
cold exposure
brown adipose tissue
fatty acid uptake
mitochondrial biogenesis
metabolic diseases

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