logo
ResearchBunny Logo
Maternal high-fat diet programs white and brown adipose tissue lipidome and transcriptome in offspring in a sex- and tissue-dependent manner in mice

Medicine and Health

Maternal high-fat diet programs white and brown adipose tissue lipidome and transcriptome in offspring in a sex- and tissue-dependent manner in mice

C. Savva, L. A. Helguero, et al.

This research reveals how a maternal high-fat diet influences the metabolic profile of offspring differently based on sex. While female offspring experience beneficial metabolic adaptations, male offspring face adverse changes. The study conducted by Christina Savva and colleagues offers intriguing insights into the long-term health implications of maternal diets.

00:00
00:00
Playback language: English
Abstract
Maternal high-fat diet (moHF) alters offspring's metabolic profile in a sex-dependent manner. Female offspring exhibit remodeled triglyceride profiles in SAT and BAT, increased thermogenesis, and enhanced brown adipocyte differentiation in BAT, potentially mitigating metabolic complications later in life. Male offspring, however, show BAT whitening, VAT hyperplasia, and impaired metabolic profiles. moHF differentially programs gene expression in WAT and BAT of both sexes.
Publisher
International Journal of Obesity
Published On
Jan 07, 2022
Authors
Christina Savva, Luisa A. Helguero, Marcela González-Granillo, Tânia Melo, Daniela Couto, Byambajav Buyandelger, Sonja Gustafsson, Jianping Liu, Maria Rosário Domingues, Xidan Li, Marion Korach-André
Tags
maternal high-fat diet
metabolic profile
sex-dependent
triglyceride profiles
thermogenesis
gene expression
brown adipocyte differentiation

Related Publications

Explore these studies to deepen your understanding of the subject.

MyD88 determines the protective effects of fish oil and perilla oil against metabolic disorders and inflammation in adipose tissue from mice fed a high-fat diet
Health and Fitness

MyD88 determines the protective effects of fish oil and perilla oil against metabolic disorders and inflammation in adipose tissue from mice fed a high-fat diet

F. Wang, M. Hu, et al.

Peripancreatic adipose tissue protects against high-fat-diet-induced hepatic steatosis and insulin resistance in mice
Medicine and Health

Peripancreatic adipose tissue protects against high-fat-diet-induced hepatic steatosis and insulin resistance in mice

B. Chanclón, Y. Wu, et al.

A diet high in sugar and fat influences neurotransmitter metabolism and then affects brain function by altering the gut microbiota
Medicine and Health

A diet high in sugar and fat influences neurotransmitter metabolism and then affects brain function by altering the gut microbiota

Y. Guo, X. Zhu, et al.

High-fiber basil seed flour reduces insulin resistance and hepatic steatosis in high-fat diet mice
Medicine and Health

High-fiber basil seed flour reduces insulin resistance and hepatic steatosis in high-fat diet mice

C. Farías, C. Cisternas, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny