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Abstract
This study investigates the link between sexual behavior, gut microbiome changes, systemic inflammation, and HIV-1 infection in men who have sex with men (MSM). It finds that unprotected receptive intercourse is associated with increased proinflammatory cytokines and decreased abundance of specific gut bacteria before HIV-1 infection, suggesting these factors mediate the effect of sexual behavior on HIV-1 acquisition.
Publisher
Communications Biology
Published On
Sep 26, 2024
Authors
Huang Lin, Yue Chen, Grace Abor-Lacks, Meaghan Price, Alison Morris, Jing Sun, Frank Palella, Kara W. Chew, Todd T. Brown, Charles R. Rinaldo, Shyamal D. Peddada
DOI
https://doi.org/10.1038/s42003-024-06816-z
Tags
HIV-1 infection
gut microbiome
systemic inflammation
sexual behavior
men who have sex with men
pro-inflammatory cytokines

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