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Oral intake of rice overexpressing ubiquitin ligase inhibitory pentapeptide prevents atrophy in denervated skeletal muscle

Medicine and Health

Oral intake of rice overexpressing ubiquitin ligase inhibitory pentapeptide prevents atrophy in denervated skeletal muscle

R. Nakao, W. Shen, et al.

This research conducted by Reiko Nakao and colleagues explores the oral absorption of a novel CBLB inhibitory pentapeptide (Cblin) for preventing muscle atrophy. Results indicate that mice fed genetically modified rice (CbR) containing Cblin experienced lesser muscle mass loss and exhibited lower levels of atrophy-related proteins, positioning CbR as a potential innovative treatment in muscle preservation.

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Playback language: English
Abstract
This study investigated whether a CBLB inhibitory pentapeptide (Cblin) could be absorbed orally and prevent muscle atrophy. Cblin, found to cross Caco-2 cell monolayers and rat plasma after oral administration, was incorporated into transgenic rice (CbR). Mice fed CbR showed prevention of denervation-induced muscle mass loss and reduced expression of muscle atrophy-related ubiquitin ligases, suggesting CbR as a potential muscle atrophy treatment.
Publisher
npj Science of Food
Published On
Sep 09, 2021
Authors
Reiko Nakao, Weilin Shen, Yasuka Shimajiri, Kumiko Kainou, Yuki Sato, Anayt Ulla, Kohta Ohnishi, Miyuki Ninomiya, Ayako Ohno, Takayuki Uchida, Mitsuru Tanaka, Kazuhito Akama, Toshiro Matsui, Takeshi Nikawa
Tags
muscle atrophy
Cblin
Caco-2 cells
genetically modified rice
oral absorption
ubiquitin ligases
denervation

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