Health and Fitness

Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle

C. A. Bishop, T. Machate, et al.

This groundbreaking study by Christopher A. Bishop and colleagues reveals that while leucine can enhance metabolic health by improving adiposity and insulin sensitivity, valine may have detrimental effects, worsening glucose tolerance and insulin signaling. Discover how branched-chain amino acids could impact your health!

00:00

Playback language: English

Index

Abstract

Conflicting data exists on the role of branched-chain amino acids (BCAAs) in metabolic health. This study investigated the individual effects of leucine and valine in mice fed high-fat diets. Leucine supplementation showed beneficial effects on adiposity and insulin sensitivity, while valine worsened high-fat diet-induced health impairments, reducing glucose tolerance and insulin sensitivity due to increased 3-hydroxyisobutyrate (3-HIB) levels, which increased basal skeletal muscle glucose uptake, leading to glucotoxicity and impaired myocyte insulin signaling.

Publisher

Nutrition and Diabetes

Published On

Apr 13, 2022

Authors

Christopher A. Bishop, Tina Machate, Thorsten Henning, Janin Henkel, Gerhard Püschel, Daniela Weber, Tilman Grune, Susanne Klaus, Karolin Weitkunat

Related Publications

Explore these studies to deepen your understanding of the subject.

Medicine and Health

The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity

F. Vanweert, S. C. Boone, et al.

Health and Fitness

In vivo oscillations of the soleus muscle can be quantified using b-mode ultrasound imaging during walking and running in humans

A. K. M. Lai and E. F. Hodson-tole

Environmental Studies and Forestry

Greenhouse gas emissions in US beef production can be reduced by up to 30% with the adoption of selected mitigation measures

R. E. O. Pelton, C. E. Kazanski, et al.

Medicine and Health

Association between fatty acids and the risk of impaired glucose tolerance and type 2 diabetes mellitus in American adults: NHANES 2005–2016

X. Zhu, L. Chen, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny