Health and Fitness

Composition of gut microbiota involved in alleviation of dexamethasone-induced muscle atrophy by whey protein

J. Qiu, Y. Cheng, et al.

This study by JinLing Qiu, Yixing Cheng, Yang Deng, Guangxu Ren, and Jiaqi Wang explores how gut microbiota influences muscle atrophy induced by dexamethasone, and reveals the promising effects of whey protein supplementation in reversing these changes and enhancing muscle function.

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Abstract

This study investigated the role of gut microbiota in dexamethasone (DEX)-induced skeletal muscle atrophy and the effect of whey protein intervention. DEX administration in mice caused shifts in gut microbiota, including reduced alpha diversity and changes in the Firmicutes/Bacteroidota ratio. Whey protein supplementation reversed these changes and improved muscle function. Stepwise regression models identified enterotypes predicting muscle function and weight, highlighting the potential of microbiota-altering interventions for mitigating muscle atrophy.

Publisher

npj Science of Food

Published On

Nov 01, 2023

Authors

JinLing Qiu, Yixing Cheng, Yang Deng, Guangxu Ren, Jiaqi Wang

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