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Abstract
This study investigated the role of gut microbiota in dexamethasone (DEX)-induced skeletal muscle atrophy and the effect of whey protein intervention. DEX administration in mice caused shifts in gut microbiota, including reduced alpha diversity and changes in the Firmicutes/Bacteroidota ratio. Whey protein supplementation reversed these changes and improved muscle function. Stepwise regression models identified enterotypes predicting muscle function and weight, highlighting the potential of microbiota-altering interventions for mitigating muscle atrophy.
Publisher
npj Science of Food
Published On
Nov 01, 2023
Authors
JinLing Qiu, Yixing Cheng, Yang Deng, Guangxu Ren, Jiaqi Wang
Tags
gut microbiota
dexamethasone
skeletal muscle atrophy
whey protein
muscle function
alpha diversity
intervention

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