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Omega-3 polyunsaturated fatty acids ameliorate PM2.5 exposure induced lung injury in mice through remodeling the gut microbiota and modulating the lung metabolism

Medicine and Health

Omega-3 polyunsaturated fatty acids ameliorate PM2.5 exposure induced lung injury in mice through remodeling the gut microbiota and modulating the lung metabolism

J. Li, Y. Chen, et al.

This exciting study conducted by Jingli Li, Yang Chen, Qiangqiang Shi, Jian Sun, Chunyi Zhang, and Lingjing Liu reveals how omega-3 polyunsaturated fatty acid supplementation has the potential to reduce lung injury, inflammation, and oxidative stress in mice exposed to PM2.5. The findings suggest a promising avenue for mitigating the effects of environmental pollutants on lung health.

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Playback language: English
Abstract
This study investigated the effects of omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on PM2.5-induced lung injury in mice. ω-3 PUFAs reduced lung injury, inflammation, and oxidative stress, altered lung metabolite profiles, and modulated the gut microbiota. Supplementation showed promise in attenuating PM2.5-induced lung injury.
Publisher
Environmental Science and Pollution Research
Published On
Jan 01, 2023
Authors
Jingli Li, Yang Chen, Qiangqiang Shi, Jian Sun, Chunyi Zhang, Lingjing Liu
Tags
omega-3 fatty acids
lung injury
PM2.5
inflammation
oxidative stress
gut microbiota
mice

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