Medicine and Health

Ablation of the gut microbiota alleviates high-methionine diet-induced hyperhomocysteinemia and glucose intolerance in mice

W. Li, Y. Jia, et al.

This study by Wenqiang Li and colleagues explores how gut microbiota influences hyperhomocysteinemia and glucose intolerance induced by a high-methionine diet in mice. Remarkably, antibiotic treatment mitigated plasma homocysteine levels and improved glucose tolerance, shedding light on the significant role of gut microbes in metabolic health.

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Abstract

This study investigated the role of gut microbiota in high-methionine (HM) diet-induced hyperhomocysteinemia (HHcy) and glucose intolerance in mice. Results showed that HM diet induced HHcy and glucose intolerance, while antibiotic treatment reduced plasma Hcy levels and reversed glucose intolerance. Gut microbiota depletion did not affect liver homocysteine metabolism but altered microbiota composition, increasing *Faecalibaculum* and *Dubosiella*, which were positively correlated with plasma Hcy. *Dubosiella newyorkensis* produced Hcy in vitro. The findings suggest that the HM diet-induced HHcy and glucose intolerance are mediated by gut microbiota-produced Hcy.

Publisher

npj Science of Food

Published On

Jul 17, 2023

Authors

Wenqiang Li, Yiting Jia, Ze Gong, Zhao Dong, Fang Yu, Yi Fu, Changtao Jiang, Wei Kong

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