Oral delivery of nano-drug delivery systems (Nano-DDS) is challenging. This research constructs core-shell mesoporous silica nanoparticles (~80 nm) with virus-like nanospikes (VSN), further modified with L-alanine (CVSN) for chiral recognition. Compared to solid silica NPs, mesoporous silica NPs, and VSN, CVSN demonstrates superior delivery by overcoming intestinal barriers. Indomethacin (IMC) encapsulated in CVSN enhances stability and solubility, while chiral nanospikes improve mucosal penetration and absorption. The versatility of CVSN as an oral Nano-DDS is also demonstrated.

Zhentao Sang, Lu Xu, Renyu Ding, Minjun Wang, Xiaoran Yang, Xitan Li, Bingxin Zhou, Kaijun Gou, Yang Han, Tingting Liu, Xuchun Chen, Ying Cheng, Huazhe Yang, Heran Li