Ligand-switchable nanoparticles resembling viral surface for | ResearchBunny

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Abstract

Mutual interference between surface ligands on multifunctional nanoparticles hinders optimal drug delivery. This study develops ligand-switchable nanoparticles mimicking viral surfaces, modified with a pH-responsive cell-penetrating peptide (Pep) and a liver-targeting moiety (Gal). Oral administration triggers Pep extension in acidic environments, enabling intestinal barrier traversal. At physiological pH, Pep folds, exposing Gal for liver targeting. Insulin-loaded nanoparticles show effective intestinal absorption, hepatic deposition, and improved glucose homeostasis in diabetic rats.

Publisher

Nature Communications

Published On

Nov 04, 2022

Authors

Tiantian Yang, Aohua Wang, Di Nie, Weiwei Fan, Xiaohe Jiang, Miaorong Yu, Shiyan Guo, Chunliu Zhu, Gang Wei, Yong Gan

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