Medicine and Health

Enhanced plant-derived vesicles for nucleotide delivery for cancer therapy

S. Corvigno, Y. Liu, et al.

This exciting research showcases the development of a hybrid exosomal polymeric system (HEXPO) using plant-derived vesicles, promising a breakthrough in cancer therapy by effectively delivering small RNAs. The study, led by a team of experts including Sara Corvigno and Anil K. Sood, highlights the anti-angiogenic potential of miR146a in combating cancer.

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Abstract

Small RNAs (miRNAs or siRNAs) are effective tools for cancer therapy, but existing carriers have limitations. Plant-derived vesicles (PDVs) offer promise as RNA carriers, but issues like insufficient loading and scalability remain. This study developed a hybrid exosomal polymeric system (HEXPO) using watermelon PDVs and a dendrimer bound to miRNA146 mimic. In vivo experiments demonstrated therapeutic efficacy and revealed miR146a's anti-angiogenic activity.

Publisher

npj Precision Oncology

Published On

Apr 06, 2024

Authors

Sara Corvigno, Yuan Liu, Emine Bayraktar, Elaine Stur, Nazende Nur Bayram, Adrian Lankenau Ahumada, Supriya Nagaraju, Cristian Rodriguez-Aguayo, Hu Chen, Thanh Chung Vu, Yunfei Wen, Han Liang, Li Zhao, Sanghoon Lee, Gabriel Lopez-Berestein, Anil K. Sood

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