This study investigates the binding mechanism of SARS-CoV-2 spike glycoprotein (S-glycoprotein) to the ACE2 receptor using atomic force microscopy (AFM). The researchers demonstrate that the receptor-binding domain (RBD) within the S-glycoprotein is the primary binding interface with ACE2. They extract kinetic and thermodynamic properties of this interaction both on model surfaces and living cells. Finally, they test several ACE2-derived peptides as potential binding inhibitors, offering new therapeutic perspectives for SARS-CoV-2 infection.
Publisher
Nature Communications
Published On
Sep 11, 2020
Authors
Jinsung Yang, Simon J. L. Petitjean, Melanie Koehler, Qingrong Zhang, Andra C. Dumitru, Wenzhang Chen, Sylvie Declercq, Stéphane P. Vincent, Patrice Soumillion, David Alsteens
Tags
SARS-CoV-2
spike glycoprotein
ACE2 receptor
binding mechanism
peptide inhibitors
therapeutic application
atomic force microscopy
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