This study investigates the impact of SARS-CoV-2 mutations on receptor binding and antibody neutralization. Using atomic force microscopy and molecular dynamics, the researchers found increased stability in the RBD-ACE2 complex for several variants of concern, particularly due to N501Y and E484Q mutations. While N501Y increased stability, it is unlikely to significantly affect antibody neutralization. The work provides detailed insights into the binding of SARS-CoV-2 variants and their impact on immunity.

Melanie Koehler, Ankita Ray, Rodrigo A. Moreira, Blinera Juniku, Adolfo B. Poma, David Alsteens