Medicine and Health

SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus

M. Dogan, L. Kozhaya, et al.

This groundbreaking study developed highly sensitive SARS-CoV-2-specific antibody and neutralization assays, revealing significant findings about antibody responses in COVID-19 patients. Conducted by a team of researchers that includes Mikail Dogan, Lina Kozhaya, and Derya Unutmaz, this research could enhance our understanding of vaccine effectiveness.

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Abstract

This study developed highly sensitive SARS-CoV-2-specific antibody and neutralization assays. All PCR+ subjects (n=115) showed SARS-CoV-2 Spike or Nucleocapsid protein-specific IgG antibodies, while negative controls did not. Neutralization was observed in COVID-19 and convalescent plasma. Hospitalized patients had significantly higher antibody and neutralization titers than outpatients or convalescent plasma donors. Some COVID-19 patients also had neutralizing antibodies against SARS-CoV. The assays' high specificity and sensitivity could improve understanding of the antibody response in COVID-19 and vaccine effectiveness.

Publisher

Communications Biology

Published On

Jan 29, 2021

Authors

Mikail Dogan, Lina Kozhaya, Lindsey Placek, Courtney Gunter, Mesut Yigit, Rachel Hardy, Matthew Plassmeyer, Paige Coatney, Kimberleigh Lillard, Zaheer Bukhari, Michael Kleinberg, Chelsea Hayes, Moshe Arditi, Ellen Klapper, Noah Merin, Bruce Tsan-Tang Liang, Raavi Gupta, Oral Alpan, Derya Unutmaz

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