Medicine and Health

Mitochondrial Oxidative Stress Is the General Reason for Apoptosis Induced by Different-Valence Heavy Metals in Cells and Mitochondria

S. M. Korotkov

This insightful review by Sergey M Korotkov delves into the intricate relationships between apoptosis, oxidative stress, and various heavy metals. Discover how metals like thallium and mercury impact cell viability, mitochondrial function, and overall cellular health. Uncover the surprising similarities and differences in their toxic effects, and the crucial roles thiol groups and iron metabolism play in this balance.

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Abstract

This review analyzes apoptosis and oxidative stress caused by different-valence heavy metals (Ag+, Tl+, Hg2+, Cd2+, Pb2+, Al3+, Ga3+, In3+, As3+, Sb3+, Cr6+, and U6+) in cells and mitochondria. Apoptosis is characterized by reduced cell viability, caspase activation, pro-apoptotic gene expression, and protein kinase activation. Oxidative stress manifests as mitochondrial permeability transition pore (MPTP) opening, mitochondrial swelling, ROS production, lipid peroxidation, cytochrome c release, decreased mitochondrial membrane potential, ATP synthesis decline, and calcium overload. The review discusses the similarities and differences in the toxic effects of these metals, particularly thallium, focusing on their interactions with thiol groups and iron metabolism.

Publisher

International Journal of Molecular Sciences

Published On

Sep 22, 2023

Authors

Sergey M Korotkov

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