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N-acetylcysteine supplementation did not reverse mitochondrial oxidative stress, apoptosis, and inflammation in the salivary glands of hyperglycemic rats

Medicine and Health

N-acetylcysteine supplementation did not reverse mitochondrial oxidative stress, apoptosis, and inflammation in the salivary glands of hyperglycemic rats

Z. Anna, K. Joanna, et al.

This study by Zalewska Anna and colleagues explores whether N-acetylcysteine supplementation can counteract harmful effects of a high-fat diet on salivary gland function in hyperglycemic rats. Discover how NAC influences mitochondrial activity and inflammatory markers, and what implications this may have for oxidative stress management.

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Playback language: English
Abstract
This study investigated whether N-acetylcysteine (NAC) supplementation could reverse the negative effects of a high-fat diet (HFD) on mitochondrial function, apoptosis, and oxidative stress in the salivary glands of hyperglycemic rats. While NAC increased the activity of some mitochondrial complexes and decreased certain inflammatory markers in parotid glands, it did not significantly improve other parameters in either parotid or submandibular glands. The findings suggest that NAC offers limited protection against free radical damage, apoptosis, and inflammation in the salivary gland mitochondria of HFD rats.
Publisher
Nutrition and Diabetes
Published On
Nov 09, 2021
Authors
Zalewska Anna, Kuć Joanna, Zięba Sara, Matczuk Jan, Kostecka-Sochoń Paula, Szarmach Izabela, Ładny Jerzy Robert, Żendzian-Piotrowska Małgorzata, Maciejczyk Mateusz
Tags
N-acetylcysteine
high-fat diet
mitochondrial function
apoptosis
oxidative stress
salivary glands
hyperglycemic rats

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