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Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho

Medicine and Health

Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho

G. P. Dias, T. Murphy, et al.

This groundbreaking study by Gisele Pereira Dias and colleagues reveals that intermittent fasting significantly outperforms daily calorie restriction in enhancing memory retention. After three months, female C57BL6 mice showed remarkable improvements in long-term memory, increased neurogenesis, and upregulation of the longevity gene *Klotho* in the hippocampus, highlighting the vital role of *Kl* in cognition and brain health.

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Playback language: English
Abstract
Daily calorie restriction (CR) and intermittent fasting (IF) enhance longevity and cognition but the effects and mechanisms that differentiate these two paradigms are unknown. This study compared IF (every-other-day feeding) to a matched 10% daily CR and ad libitum conditions in female C57BL6 mice. After 3 months, IF improved long-term memory retention, increased hippocampal neurogenesis (AHN), and upregulated the longevity gene *Klotho* (*Kl*) in the hippocampus. Downregulating *Kl* in human hippocampal progenitor cells decreased neurogenesis, while overexpression increased it. *Kl* knockout mice showed impaired AHN. The findings suggest IF is superior to 10% CR for enhancing memory, and identify *Kl* as a key regulator of IF's effects on cognition through AHN.
Publisher
Nature Communications
Published On
May 25, 2021
Authors
Gisele Pereira Dias, Tytus Murphy, Doris Stangl, Selda Ahmet, Benjamin Morisse, Alina Nix, Lindsey J. Aimone, James B. Aimone, Makoto Kuro-O, Fred H. Gage, Sandrine Thuret
Tags
intermittent fasting
calorie restriction
memory retention
neurogenesis
Klotho
hippocampus
C57BL6 mice

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