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Abstract
This study investigates the long-term prognosis and educational determinants of brain network decline in older adults. Longitudinal imaging data from 265 participants (age 45-86) revealed that older adults (≥65 years) without a college degree showed greater decline in large-scale functional brain network organization (resting-state system segregation) than their college-educated peers. This decline predicted future dementia severity up to 10 years post-scan, independent of APOE status, AD-related pathology, and cortical thinning. These findings highlight the trajectory of brain network organization as a unique indicator of brain health in older age, influenced by educational attainment.
Publisher
Nature Aging
Published On
Nov 11, 2021
Authors
Micaela Y. Chan, Liang Han, Claudia A. Carreno, Ziwei Zhang, Rebekah M. Rodriguez, Megan LaRose, Jason Hassenstab, Gagan S. Wig
Tags
brain network decline
older adults
educational attainment
functional brain organization
dementia severity
longitudinal study

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