logo
ResearchBunny Logo
Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice

Medicine and Health

Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice

N. Forte, S. Boccella, et al.

This groundbreaking study reveals how the interplay of orexin-A and endocannabinoid signaling contributes to hippocampal dysfunction in obesity. Conducted by a team of experts including Nicola Forte and Serena Boccella, it uncovers the molecular mechanisms behind memory impairments linked to obesity, paving the way for potential therapeutic interventions.

00:00
00:00
Playback language: English
Abstract
This study investigates the role of orexin-A/hypocretin-1 and endocannabinoid 2-arachidonoylglycerol signaling in obesity-associated hippocampal dysfunction. The researchers demonstrate that excessive orexin-A/2-arachidonoylglycerol/cannabinoid receptor type-1 signaling leads to impaired adult hippocampal neurogenesis, reduced plasticity, and impaired pattern separation, impacting episodic memory. Inhibiting orexin-A action at orexin-1 receptors rescued these deficits, providing a molecular mechanism for episodic memory alterations in obesity.
Publisher
NATURE COMMUNICATIONS
Published On
Oct 21, 2021
Authors
Nicola Forte, Serena Boccella, Lea Tunisi, Alba Clara Fernández-Rilo, Roberta Imperatore, Fabio Arturo Iannotti, Maria De Risi, Monica Iannotta, Fabiana Piscitelli, Raffaele Capasso, Paolo De Girolamo, Elvira De Leonibus, Sabatino Maione, Vincenzo Di Marzo, Luigia Cristino
Tags
obesity
hippocampal dysfunction
orexin-A
endocannabinoids
neurogenesis
memory
pattern separation

Related Publications

Explore these studies to deepen your understanding of the subject.

Dynamic and stable hippocampal representations of social identity and reward expectation support associative social memory in male mice
Psychology

Dynamic and stable hippocampal representations of social identity and reward expectation support associative social memory in male mice

E. Kong, K. Lee, et al.

Higher habitual intakes of flavonoids and flavonoid-rich foods are associated with a lower incidence of type 2 diabetes in the UK Biobank cohort
Medicine and Health

Higher habitual intakes of flavonoids and flavonoid-rich foods are associated with a lower incidence of type 2 diabetes in the UK Biobank cohort

A. S. Thompson, A. Jennings, et al.

Exercise mitigates a gut microbiota-mediated reduction in adult hippocampal neurogenesis and associated behaviours in rats
Medicine and Health

Exercise mitigates a gut microbiota-mediated reduction in adult hippocampal neurogenesis and associated behaviours in rats

S. Nicolas, S. Dohm-hansen, et al.

Is Lennie a monster? A reconsideration of Steinbeck's Of Mice and Men in a 21st century inclusive classroom context
Education

Is Lennie a monster? A reconsideration of Steinbeck's Of Mice and Men in a 21st century inclusive classroom context

C. Lawrence

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny